Is it possible to replace the roms in those 2-in-1 GBA games?

So as the title reads, is it possible to replace the 2 rom files in any of the many 2-in-1 GBA games that were released over the years, pretty much any of those seen on this page: https://www.google.com/search?q=gba...XXLc0KHdVCBJoQ_AUoAnoECA4QBA&biw=1920&bih=920

You might think it pointless to do when we have flashcards and emulators, and...

Is it possible to replace the roms in those 2-in-1 GBA games?